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KMID : 0364019760090020239
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Korean Journal of Thoracic and Cardiovascular Surgery
1976 Volume.9 No. 2 p.239 ~ p.244
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The Effect of Cardiopulomnary Bypass on Serum Magnesium
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蔡憲/Chae, Hurn
盧浚亮/徐景弼/李寧均/Rho, Joon Ryang/Suh, Kyung Phill/Lee, Yung-Kyoon
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Abstract
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Alterations in the serum magnesium level were studied in twenty patients who had open-heart surgery during the period from August 1974 to May 1975. The patients were chosen at random. The operative procedures included repair for´ congenital heart diseases in fifteen patients and cardiac valve replacement for acquired valvular heart diseases in five patients.
The age ranged from 8 to 46 years, with an average of 19 years. None of the patients had a history of gross neuromuscular abnormalities. Cardiopulmonary bypass was carried out using a roller pump and a disposable oxygenator. The prime solution consisted of 2 units of ACD banked blood and approximately an equal volume of non-blood additives in adults, while a relatively smaller volume was added in children. The average flow rate was 2,733 ml per minute.
Blood samples for magnesium and arterial blood pH were obtained the day after admission 15 minutes after initiation of the bypass and on the morning the day after operation.
Preoperative data were then compared with those obtained during the bypass and postoperatively by a paired test.
During the bypass, the serum magnesium level decreased significantly from 1.425±0.029 to 1.210±0.063 mEq. liter (p<0.001). Also, there was a significant decrease in serum magnesium from 1.425±0.029 preoperatively to 1.255±0.083 mEq. per liter p<0.001). Also, there was a significant decrease in serum magnesium from 1.425±0.029 preoperatively to 1.255±0.083 mEq. per liter postoperatively (p<0.01) The duration of bypass was less than 90 minutes in 10 patients (group A) and exceeded 90 minutes in the remaining 10 (group B). There was no statistical correlation between the groups A and B (p≫0.20).
Statistical analyses of the serum magnesium level and arterial blood pH showed no sigificant correlation with correlation coefficient; being -0.3485 (pre-op), -0.2971 (during bypass), and -0.1008 (post-op), respectively. In all the patients, no gross neuromuscular abnormalities were found postoperatively.
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